A DRUG INTERACTION STUDY INVESTIGATING THE EFFECT OF RIFABUTIN ON THE PHARMACOKINETICS OF MARAVIROC IN HEALTHY SUBJECTS.

A drug interaction study investigating the effect of Rifabutin on the pharmacokinetics of Maraviroc in healthy subjects.

Effects of steady-state rifabutin on the pharmacokinetics of steady-state maraviroc were investigated in fourteen healthy adult female and male volunteers.Maraviroc 300 mg twice daily (BID) was given orally with food for fifteen days.On day six, rifabutin 300 mg once daily Wired Mouse (QD, P.O.) was added to the regimen.Formal pharmacokinetic (PK)

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Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules

Height Adjuster Abstract Background Motor neuron degeneration or loss in the spinal cord is the characteristic phenotype of motor neuron diseases or spinal cord injuries.Being proliferative and located near neurons, astrocytes are considered ideal cell sources for regenerating neurons.Methods We selected and tested different combinations of the sma

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Dirt analysis on the performance of an engine cooling system

This present work looked at the effect of sand blocking the heat transfer area of the radiator ABSOLUTE IRON and its effect on the engine coolant through the conduct of experiments and a mathematical model developed.The results indicated that the percentage area covered resulted in a proportional increase of the inlet and outlet temperatures of the

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The Efficacy of Generic Daclatasvir-Sofosbuvir as Pan-Genotypic Regiment for Hepatitis C Virus (HCV) Infected Patients in Bandung Indonesia

Background: Direct-acting antivirals (DAAs) have altered the prognosis of hepatitis C virus (HCV) disease but its access is limited by socioeconomic factors.Generic DAAs with lower prices were available in Indonesia in 2016.The aim of this study was to determine the efficacy of generic daclatasvir-sofosbuvir.Method: We performed an observational st

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